Proteomics Technologies |
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Proteomik
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Customers and Partners benefit from Proteome Factory’s high quality contract research and fee-for-service in proteomics, protein quantification, identification, characterization and validation because of Proteome Factory's |
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Comprehensive PFA-Proteomics Platform
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Proteome Factory uses routinely several gel-based and gel-free proteomics approaches of its PFA-Proteomics Platform in contract research projects and internal R&D. |
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Proteomics
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Proteome Factory’s extreme high resolution 2DE gel electrophoresis platform increases the probability to find and identify high-valued biomarker and target proteins significantly. The 2DE platform is based on the invention of Professor Klose (Klose and Kobalz, Electrophoresis, 1995, 16, 1034-59) which is still the most powerful proteomics separation technique today. Depending on gel size several thousand up to 10,000 protein spots can be separated in one experiment. In combination with optimized sample prefractionation (e.g. depletion of abundant plasma proteins) and sample preparation of organs, tissue, cells in culture or body fluids Proteome Factory’s 2DE technique is superior compared to commercial available IPG gel based 2DE methods. |
Hochauflösende 2D Elektrophorese für die Proteomik Mit zunehmender Größe der 2D Elektrophorese Gele nimmt ihr Auflösungsvermögen bis zu vielen Tausend Proteinspots zu. Ideal für hochauflösende Proteomik Studien zur Erfassung möglichst vieler regulierter Proteine, potentieller Biomarker und Targets in einerm Experiment. Die 60x30 cm großen 2DE Gele erlauben eine Abdeckung des pI-Bereiches bis ca. pH 11,5 und sind somit auch für die Analyse hoch basischer Protein sehr gut geeignet. |
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Depletion of high abundant proteins
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Proteome analysis of plasma/serum and CSF is an important method to discover biomarkers and protein targets by comparison of disease- or therapy-associated samples with control samples which are the basis for development of new diagnostic tools and therapies. |
2DE of plasma with and without depletion of high a |
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Automation in Proteomics
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Proteome Factory uses automation in many parts of its PFA-Proteomics Platform to enhance reproducibility and throughput and to prevent contaminations for example by keratin. |
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